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Scripps Research Scientists Devise Powerful New Method For Finding Therapeutic Antibodies
Date: Sep-13-2012Scientists at The Scripps Research Institute have found a new technique that should greatly speed the discovery of medically and scientifically useful antibodies, immune system proteins that detect and destroy invaders such as bacteria and viruses. New methods to discover antibodies are important because antibodies make up the fastest growing sector of human therapeutics; it is estimated that by 2014 the top-three selling drugs worldwide will be antibodies...
Preclinical Data Shows 100 Percent Prevention And Treatment Of Influenza With Engineered Human Antibody
Date: Sep-13-2012Visterra, Inc., developer of novel therapeutics to treat major diseases, today announced the presentation of positive data from a preclinical study evaluating the efficacy of the company's lead product candidate, VIS410, a broadly protective, fully human monoclonal antibody being developed for influenza A infections. Data from preclinical studies were presented today at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco. These data were also selected by ICAAC to be included in the public communication highlights for the meeting...
Protein Linked To Therapy Resistance In Breast Cancer
Date: Sep-13-2012A gene that may possibly belong to an entire new family of oncogenes has been linked by researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) with breast cancer resistance to a well-regarded and widely used cancer therapy. One of the world's leading breast cancer researchers, Mina Bissell, Distinguished Scientist with Berkeley Lab's Life Sciences Division, led a study in which a protein known as FAM83A was linked to resistance to the cancer drugs known as EGFR-TKIs (Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors)...
RV144 Vaccine Efficacy Increased Against Certain HIV Viruses
Date: Sep-13-2012Scientists used genetic sequencing to discover new evidence that the first vaccine shown to prevent HIV infection in people also affected the viruses in those who did become infected. Viruses with two genetic "footprints" were associated with greater vaccine efficacy. The results were published today in the online edition of the journal Nature. "This is the first time that we have seen pressure on the virus at the genetic level due to an effective HIV vaccine," said Morgane Rolland, Ph.D., a scientist at the U.S. Military HIV Research Program and lead author of the study...
Genetics Society Of America's Genetics Journal Highlights For September 2012
Date: Sep-13-2012Listed below are the selected highlights for the September 2012 issue of the Genetics Society of America's journal, GENETICS. The September issue is available online here: GENETICS, Vol. 192, September 2012. ISSUE HIGHLIGHTS Weak selection and protein evolution, pp. 15-31 Hiroshi Akashi, Naoki Osada, and Tomoko Ohta The rapid proliferation of genome sequence data has renewed interest in the causes of molecular evolution...
Bacteria That Cause Disease In Humans Have 'Reversible Switching Mechanism' Allowing Them To Adapt To Environments Lacking Oxygen
Date: Sep-13-2012Bacteria that cause disease in humans have a 'reversible switching mechanism' that allows them to adapt to environments lacking oxygen, scientists at the University of East Anglia (UEA) have found. Published in the journal Proceedings of the National Academy of Sciences USA, the findings provide a new insight into how bacteria sense and adapt to oxygenated atmospheres, and uncover a new 'antioxidant' pathway by which certain types of damaged proteins can be repaired...
Swim Training Plus Healthy Diet Factor In Cancer Fight: New Study
Date: Sep-13-2012A new study published in the journal Applied Physiology, Nutrition, and Metabolism (APNM) reaffirms the crucial role exercise along with good nutrition play in maintaining health and fighting disease. "Hepatocellular carcinoma (HCC) is the fifth most frequent cancer worldwide, ranking third among all cancer-related deaths. Clinical and experimental studies have shown that physical exercise helps to prevent cancer and improving quality of life," says Dr...
New Genetic Mechanism For Controlling Blood Cell Development And Blood Vessel Integrity Found
Date: Sep-13-2012The protein GATA2 is known as a "master regulator" of blood cell development. When a mutation occurs in the gene that makes GATA2, serious blood diseases such as acute myeloid leukemia can result. Zooming in on the GATA2 gene, UW-Madison researchers and their collaborators at the National Institutes of Health (NIH) have discovered unexpectedly that a small DNA sequence drives this powerful master regulator...
Wnt Signaling Pathway Plays Key Role In Adult Nerve Cell Generation
Date: Sep-13-2012Researchers from the University of Utah have gained new insight into the regulation of adult nerve cell generation in the hypothalamus, the part of the brain that regulates many aspects of behavior, mood, and metabolism. In the Sept. 10, 2012, issue of Developmental Cell they report that a cell-to-cell communication network known as the Wnt signaling pathway plays an important role in both the production and specialization of nerve cell precursors in the hypothalamus. The hypothalamus is a highly complex region of the brain that controls hunger, thirst, fatigue, body temperature, and sleep...
Toothpicks And Surgical Swabs Can Wreak Havoc In The Gut When Inadvertently Swallowed Or Left Behind After Surgery
Date: Sep-13-2012A woman developed severe blood poisoning (sepsis) and a liver abscess, after inadvertently swallowing a toothpick, which perforated her gullet and lodged in a lobe of her liver, reveals a case published in BMJ Case Reports. Swallowing "foreign bodies" is relatively common, particularly among children, but the subsequent development of a liver abscess is rare, with the first recorded incident dating back to 1898, the authors point out. But it has mostly been associated with inadvertently swallowing pins, nails, fish and chicken bones, rather than toothpicks...
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