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Diverse Metabolic Roles Revealed For PML Tumor Suppressor Gene
Date: Sep-03-2012Two papers led by scientific teams from the Cancer Genetics Program at Beth Israel Deaconess Medical Center (BIDMC) shed new light on the genetic mechanisms underlying cellular energy and metabolism and, at the same time, highlight both the challenges and opportunities of genetic approaches to cancer treatment...
Potential New Medical Uses For Flexible Electronics Technology
Date: Sep-03-2012A Wayne State University researcher has developed technology that opens new possibilities for health care and medical applications of electronic devices. Yong Xu, associate professor of electrical and computer engineering in the College of Engineering, has developed a simple technology compatible with silicon-on-insulator (SOI) complementary-metal-oxide-semiconductor (CMOS) processes for making flexible electronics...
Acts Of Terror Or Political Aggression May Be Predicted By Leaders' Emotional Cues
Date: Sep-03-2012Leaders often use rousing speeches to evoke powerful emotions, and those emotions may predict when a group will commit an act of violence or terrorism, according to new research published in the journal Behavioral Sciences of Terrorism and Political Aggression. Analysis of speeches delivered by government, activist and terrorist leaders found that leaders' expressions of anger, contempt and disgust spiked immediately before their group committed an act of violence...
Microcirculation Of Malaria-Infected Red Blood Cells Impeded By Protein
Date: Sep-03-2012When the parasite responsible for malaria infects human red blood cells, it launches a 48-hour remodeling of the host cells. During the first 24 hours of this cycle, a protein called RESA undertakes the first step of renovation: enhancing the stiffness of the cell membranes. That increased rigidity impairs red blood cells' ability to travel through the blood vessels, especially at fever temperatures, according to a new study from researchers at MIT, the Institut Pasteur and the Korea Advanced Institute of Science and Technology (KAIST)...
Cardiometabolic Risks And Sexual Health
Date: Sep-03-2012Assessment of sexual function should be incorporated into cardiovascular risk evaluation for all men, regardless of the presence or absence of known cardiovascular disease, according to Dr. Ajay Nehra, lead author of a report by the Princeton Consensus (Expert Panel) Conference, a collaboration of 22 international, multispecialty researchers. Nehra is vice chairperson, professor and director of Men's Health in the Department of Urology at Rush University Medical Center in Chicago...
A Possible Therapy For Tamoxifen-Resistant Breast Cancer Identified
Date: Sep-03-2012A study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has discovered how tamoxifen-resistant breast-cancer cells grow and proliferate. It also suggests that an experimental agent might offer a novel targeted therapy for tamoxifen-resistant breast cancer. Like a second door that opens after the first door closes, a signaling pathway called hedgehog (Hhg) can promote the growth of breast-cancer cells after tamoxifen shuts down the pathway activated by the hormone estrogen...
Tax Incentives For Living Organ Donors
Date: Sep-03-2012The policies that several states have adopted giving tax deductions or credits to living organ donors do not appear to have increased donation rates. Authors of the study, appearing in the American Journal of Transplantation, found little difference in the annual number of living organ donations per 100,000 population between the 15 states that had enacted some sort of tax benefit as of 2009 and states having no such policy at that time...
Combined Chemotherapy Effective For Immunodeficient Patients With Secondary Lung Disease
Date: Sep-03-2012A team of researchers at the Medical College of Wisconsin and Children's Hospital of Wisconsin Research Institute defined a new treatment for a potentially fatal lung disease in patients with a primary immunodeficiency known as common variable immunodeficiency (CVID).The findings are published in the Journal of Clinical Immunology. Common variable immunodeficiency (CVID) is the most common primary immunodeficiency that requires regular treatment with medication, specifically immunoglobulin (antibodies) replacement therapy...
Experimental Vaccine Therapies Complicated By Cancer 'Turning Off' Important Immune Cells
Date: Sep-03-2012A research report published in the September 2012 issue of the Journal of Leukocyte Biology offers a possible explanation of why some cancer vaccines are not as effective as hoped, while at the same time identifies a new therapeutic strategy for treating autoimmune problems. In the report, scientists suggest that cancer, even in the very early stages, produces a negative immune response from dendritic cells, which prevent lymphocytes from working against the disease...
Blood Pressure Lowered By Kidney Stenting In Patients With Severe Hypertension
Date: Sep-03-2012Patients with uncontrolled renovascular hypertension saw a significant improvement in their blood pressure with renal artery stent deployment. The multicenter HERCULES trial, evaluating the safety and effectiveness of the RX Herculink Elite Stent, found that patients with higher blood pressure levels at baseline had the most dramatic reduction in blood pressure following intervention. Trial details appear in Catheterization and Cardiovascular Interventions, a journal published by Wiley on behalf of the Society for Cardiovascular Angiography and Interventions (SCAI)...
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