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Combining BRAF Inhibitor And Immunotherapy Increases Antitumor Activity In Metastatic Melanoma
Date: Aug-17-2012BRAF Inhibitor Zelboraf Boosts Effectiveness of Immunotherapy in Mouse ModelCombining the recently approved BRAF inhibitor, Zelboraf with an engineered T cell immunotherapy to treat metastatic melanoma significantly increased tumor responses and survival in an animal model, researchers at UCLA's Jonsson Comprehensive Cancer Center have shown. The animals in the study that received the combination therapy had better tumor responses and lived more than twice as long as those getting the BRAF inhibitor or immunotherapy alone...
Coordinated Protein Breakdown And Synthesis: A Key To Healthy Growth Of Cells
Date: Aug-17-2012Discovery has implications for cancer and diabetes research The cells in our bodies are involved in a continuous process of breakdown and re-growth that is essential to life itself. During a process that can be likened to self-cannibalism, the proteins within the cells are broken down into their component amino acids, which then act as the building blocks for the growth and renewal of cells. Serious diseases may result from a disruption of this process. This is the case with cancer, where cancerous cells grow quickly, but the ability of the cells to digest themselves is compromised...
Diabetes Researchers Tackle 'The Data Dilemma'
Date: Aug-17-2012Advanced data analysis is helping scientists to find and validate gene signatures linked to diabetes, says Carl-Johan Ivarsson, President of Qlucore, so that treatments can be matched to individual patients more closely Diabetes is a common life-long health condition. According to Diabetes UK, there are nearly 3 million people diagnosed with diabetes in the UK, and an estimated 850,000 people who have the condition but don't know it...
Link Discovered Between BPA And Narrowing Of The Arteries
Date: Aug-17-2012A research team from the Peninsula College of Medicine and Dentistry (PCMD), University of Exeter, and University of Cambridge has for the first time established a link between high levels of urinary Bisphenol-A (BPA) and severe coronary artery stenosis (narrowing of the arteries). The study is published in PLoS ONE. The team analysed data from 591 patients who participated in the Metabonomics and Genomics Coronary Artery Disease (MaGiCAD) study in Cambridgeshire, UK. They compared urinary BPA with grades of severity of coronary artery disease (CAD)...
Compound In Breast Milk Associated With Reduced Transmission From HIV-Infected Mother To Infant
Date: Aug-17-2012An international team of researchers has found that certain bioactive components found in human milk are associated with a reduced risk of HIV transmission from an HIV infected mother to her breast-fed infant. Their study will be published in the American Journal of Clinical Nutrition. "In developing countries, HIV-infected mothers are faced with the decision of whether or not to breastfeed their babies," said Lars Bode, PhD, assistant professor in the Department of Pediatrics at the University of California, San Diego School of Medicine...
Neurodegeneration Unexpectedly Delayed In Mice By Blocking Destruction Of Defective Proteins
Date: Aug-17-2012One might expect that ridding a brain cell of damaged proteins would be a universally good thing, and that impairing the cell's ability to do this would allow the faulty proteins to accumulate within the cell, possibly to toxic levels. So a lot of scientific effort has gone into looking for ways to enhance the process by which cells dispose of banged-up proteins. But this thinking may need some revision, according to a new study from the Stanford University School of Medicine...
Identification Of Gut Bacteria Linked To Obesity And Metabolic Syndrome
Date: Aug-17-2012Researchers at the University of Maryland School of Medicine have identified 26 species of bacteria in the human gut microbiota that appear to be linked to obesity and related metabolic complications. These include insulin resistance, high blood sugar levels, increased blood pressure and high cholesterol, known collectively as "the metabolic syndrome," which significantly increases an individual's risk of developing diabetes, cardiovascular disease and stroke. The results of the study, which analyzed data from the Old Order Amish in Lancaster County, Pa...
Diagnosis Of Neural Diseases Through The Eyes Using Color-Coded Markers
Date: Aug-17-2012Sticky plaques of proteins called amyloids mark several different, though related degenerative brain diseases including Alzheimer's, Parkinson's and Creutzfeld-Jacobs. The symptoms of these disorders overlap and methods to diagnose and monitor them are not very advanced. To solve this problem, scientists at the University of California, San Diego, have devised several new fluorescent probes that change color depending on what type of amyloid they encounter...
Concern In Australia For Alcohol/Energy Drink Consumers
Date: Aug-17-2012Not only have energy drinks become increasingly popular among adolescents and young adults in recent years, so too has mixing and drinking them with alcohol. However, research on the subjective psychological, physiological, and behavioral risk-taking outcomes of alcohol/energy drinks has had mixed results. A first-of-its-kind study compares the outcomes of alcohol/energy drinks with alcohol-only drinks among members of the Australian public. Results will be published in the November 2012 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View...
New Research Indicates Up To 60 Million Americans Suffer From Hammertoe Foot Deformities
Date: Aug-17-2012Nextremity Solutions, Inc. announced preliminarily results of a new market research analysis indicating that forefoot deformities, such as hammertoes, are an endemic problem in the United States affecting as many as 20% of Americans. According to Andrew Park, Senior Manager, Orthopedics at iDATA Research, a global medical device and pharmaceutical market intelligence firm, commented, "People who suffer from forefoot deformities remain one of the largest untreated orthopedic patient populations our firm has ever measured...
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