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Physical Activity In Premenopausal Women Reduces Hormone That Inhibits Bone Formation

Date: Aug-16-2012
A study to be published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM) suggests that physical activity for premenopausal women is very effective in reducing sclerostin - a known inhibitor of bone formation. In addition, physical training enhances IGF-1levels, which have a very positive effect on bone formation. Bone is a tissue that is always changing due to hormonal changes and physical activity, or lack thereof. Sclerostin is a glycoprotein produced almost exclusively by osteocytes, the most abundant cells found in human bone...

Breast Cancer Patients Benefit From Pre-Test Genetic Counseling

Date: Aug-16-2012
Researchers at Moffitt Cancer Center have found that when breast cancer patients are offered pre-test genetic counseling before definitive breast cancer surgery, patients exhibited decreases in distress. Those offered pre-test genetic counseling after surgery improved their informed decision-making. Patients in both groups showed increases in their cancer knowledge with pre-test genetic counseling. The study, supported in party by the American Cancer Society (MRSG CPPB-111062), appeared in a recent issue of the Annals of Surgical Oncology...

Newer Imaging Technique Reveals Glymphatic System - Previously Unknown Cleansing System In Brain

Date: Aug-16-2012
A previously unrecognized system that drains waste from the brain at a rapid clip has been discovered by neuroscientists at the University of Rochester Medical Center. The findings were published online August 15 in Science Translational Medicine. The highly organized system acts like a series of pipes that piggyback on the brain's blood vessels, sort of a shadow plumbing system that seems to serve much the same function in the brain as the lymph system does in the rest of the body - to drain away waste products...

Exploiting The Creative Brain Through Crowdsourcing

Date: Aug-16-2012
In 1714, the British government held a contest. They offered a large cash prize to anyone who could solve the vexing "longitude problem" - how to determine a ship's east/west position on the open ocean - since none of their naval experts had been able to do so. Lots of people gave it a try. One of them, a self-educated carpenter named John Harrison, invented the marine chronometer - a rugged and highly precise clock - that did the trick. For the first time, sailors could accurately determine their location at sea. A centuries-old problem was solved. And, arguably, crowdsourcing was born...

Don't Let A History Of Unsuccessful Weight Loss Deter You From Future Attempts To Lose Weight

Date: Aug-16-2012
Yo-yo dieting - the repetitive loss and regain of body weight, also called weight cycling - is prevalent in the Western world, affecting an estimated 10 percent to 40 percent of the population. The degree to which weight cycling may impact metabolism or thwart a person's ability to lose weight in the long run has been unclear - until now. A new study by researchers at Fred Hutchinson Cancer Research Center, published online in the journal Metabolism, for the first time has shown that a history of yo-yo dieting does not negatively affect metabolism or the ability to lose weight long term...

Breast Cancer Patients With Bone Metastases Benefit From Denosumab

Date: Aug-16-2012
Treatment with denosumab resulted in a greater reduction in skeletal-related events in patients with breast cancer that spread to the bones compared with zoledronic acid, while also maintaining health-related quality of life, according to the results of a phase III study published in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Our data indicate that denosumab should be the treatment of choice for the prevention of skeletal-related events and hypercalcemia in patients with breast cancer that has metastasized to the bone," said Miguel Martin, M.D...

Chemotherapy's Side Effects May Be Dramatically Reduced In The Future

Date: Aug-16-2012
Researchers in Leuven (VIB/KU Leuven) have confirmed their hypothesis that normalizing blood vessels by blocking oxygen sensor PHD2 would make chemotherapy more effective. They also demonstrated for the first time that this strategy would reduce the harmful side effects of chemotherapy on healthy organs. Limited success of chemotherapy The effectiveness of chemotherapy is first and foremost limited by the difficulties of delivering the anticancer drugs to the actual tumor...

New Photoacoustic Technique Detects Multiple Nerve Agents Simultaneously

Date: Aug-16-2012
To warn of chemical attacks and help save lives, it's vital to quickly determine if even trace levels of potentially deadly chemicals - such as the nerve gas sarin and other odorless, colorless agents - are present. U.S. Army researchers have developed a new chemical sensor that can simultaneously identify a potentially limitless numbers of agents, in real time. A paper describing the system has been published in the Optical Society's (OSA) journal, Optics Letters...

Like Bacteria, Cancer Cells Rely On Communication And Cooperation

Date: Aug-16-2012
Experts agree that, more than ever before, modern wars will be fought in the cyber zone, targeting an enemy's communications technology to cause untold damage. Now a Tel Aviv University researcher is suggesting that the same tactics should be employed in the battle against one of the body's deadliest enemies - cancer. In an article published in Trends in Microbiology, Prof. Eshel Ben-Jacob of TAU's School of Physics and Astronomy and Prof. Herbert Levine of Rice University, long-time bacteria researchers, and Prof...

Seeking Better Understanding Of Depression

Date: Aug-16-2012
Connecting the dots between two molecules whose levels are decreased in depression and increased by current antidepressants could yield new therapies, researchers say. Serotonin is a neurotransmitter that enables brain cells to communicate and brain-derived neurotropic factor, or BDNF, is a brain-nourishing molecule that also aids connectivity. Popular antidepressants such as Prozac, developed to increase levels of serotonin, have recently been found to also increase BDNF levels, said Dr...