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For Treatment Of Parasitic Infections, Antisense Approach Promising
Date: Aug-15-2012A targeted approach to treating toxoplasmosis, a parasitic disease, shows early promise in test-tube and animal studies, where it prevented the parasites from making selected proteins. When tested in newly infected mice, it reduced the number of viable parasites by more than 90 percent, researchers from the University of Chicago Medicine report in the Proceedings of the National Academy of Sciences...
Personalized Clinical Trial For Cancer Therapies May Be Possible With New Method
Date: Aug-15-2012A new tool to observe cell behavior has revealed surprising clues about how cancer cells respond to therapy - and may offer a way to further refine personalized cancer treatments. The approach, developed by investigators at Vanderbilt-Ingram Cancer Center, shows that erlotinib - a targeted therapy that acts on a growth factor receptor mutated in some lung, brain and other cancers - doesn't simply kill tumor cells as was previously assumed. The drug also causes some tumor cells to go into a non-dividing (quiescent) state or to slow down their rate of division...
Victims Of Philippine Floods Offered Seeds Of Hope
Date: Aug-15-2012Amidst horrendous flooding around Manila and major rice-growing across Luzon in the Philippines, some good news has emerged for rice farmers - Submarino rice - rice that can survive around 2 weeks of being under water. Rice is unique because it can grow well in wet conditions where other crops cannot, but if it is covered with water completely it can die, leaving flooded farmers bereft of income. Submarino rice was bred by the International Rice Research Institute (IRRI) and can survive floods if they occur before flowering...
New Method Introduced To Closely Model Diseases Caused By Splicing Defects
Date: Aug-15-2012A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases - those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders to cancer. The new modeling approach can provide unique insights into how certain diseases progress and is likely to boost efforts to develop novel treatments...
Appearance Matters More Than Health To Young Adults
Date: Aug-15-2012When it comes to college-age individuals taking care of their bodies, appearance is more important than health, research conducted at the University of Missouri suggests. MarÃa Len-RÃos, an associate professor of strategic communication, Suzanne Burgoyne, a professor of theater, and a team of undergraduate researchers studied how college-age women view their bodies and how they feel about media messages aimed at women...
White Matter Development In The Postnatal Brain Impacted By External Stimulation
Date: Aug-15-2012A team at Children's National Medical Center has found that external stimulation has an impact on the postnatal development of a specific region of the brain. Published in Nature Neuroscience, the study used sensory deprivation to look at the growth and collection of NG2-expressing oligodendrocyte progenitor cells (NG2 cells) in the sensory cortex of the brain. This type of research is part of the Center for Neuroscience Research focus on understanding the development and treatment of white matter diseases...
Canada's Freshwaters Polluted With Potent Human Toxins
Date: Aug-15-2012Nutrient pollution, one of the greatest threats to our freshwater resources, is responsible for the algal blooms that blanket our lakes and waterways in summer months. Large blooms of cyanobacteria ('blue green algae') can cause fish kills, increase the cost of drinking water treatment, devalue shoreline properties, and pose health risks to people, pets, and wildlife. A new paper just published in the Canadian Journal of Fisheries and Aquatic Sciences shows that microcystin, a toxin produced by cyanobacteria, is present in Canadian lakes in every province...
How Cancer Cells "Hijack" A Mechanism To Grow
Date: Aug-15-2012Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have discovered a mechanism that explains how some cancer cells "hijack" a biological process to potentially activate cell growth and the survival of cancer gene expression. Their study appeared in a recent issue of Nature Structural & Molecular Biology. The newly discovered mechanism involves histones (highly alkaline proteins found in cells that package and order DNA), and in this case, histone H2B, one of the five main histone proteins involved in the structure of chromatin...
Libya Faces Mental Health Crisis
Date: Aug-15-2012Libya is facing a mental health crisis with experts warning of a lack of qualified health professionals to deal with the problem. In the first-ever study of the effect of Libya's conflict on the mental health of its populations, researchers at The University of Queensland (UQ) have estimated the prevalence of post-traumatic stress disorder (PTSD) and depression in Libya since the country's 2011 civil conflict...
Mechanisms Of Acquired Chemoresistance In Ovarian Cancer Identified
Date: Aug-15-2012The presence of multiple ovarian cancer genomes in an individual patient and the absence or downregulation of the gene LRP1B are associated with the development of chemoresistance in women with the high-grade serous cancer subtype of ovarian cancer whose disease recurs after primary treatment. These study results are published in Cancer Research, a journal of the American Association for Cancer Research. David Bowtell, Ph.D...
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