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In Animal Model Of Liver Disease, New Drug Successfully Halts Fibrosis
Date: Aug-09-2012A study published in the online journal Hepatology reports a potential new NADPH oxidase (NOX) inhibitor therapy for liver fibrosis, a scarring process associated with chronic liver disease that can lead to loss of liver function. "While numerous studies have now demonstrated that advanced liver fibrosis in patients and in experimental rodent models is reversible, there is currently no effective therapy for patients," said principal investigator David A. Brenner, MD, vice chancellor for Health Sciences and dean of the School of Medicine at the University of California, San Diego...
Recent Progress In Alzheimer's Research
Date: Aug-09-2012The global market value of Alzheimer's disease therapeutics could soar to the $8 billion range once therapeutics are approved that actually change the course of the disease, reports Genetic Engineering & Biotechnology News (GEN). The current therapeutic market is valued at $3 to $4 billion, shared among drugs that temporarily delay disease progression or address the symptoms but do not alter the underlying disease, according to a recent issue of GEN...
Enrollment Of Kids In Health-Care Programs Boosted By Increasing Federal Match Funds For States
Date: Aug-09-2012Significantly more children get health insurance coverage after increases in federal matching funds to states for Medicaid and the Children's Health Insurance Program (CHIP), according to new research from the University of Michigan. The research, published in the journal Health Affairs, showed that a 10-percentage-point increase in the federal match for Medicaid and CHIP, similar to the increase that occurred with the American Reinvestment and Recovery Act, is associated with an increase of 1...
The Feasibility Of Integration Of Active Tuberculosis Case Finding In A Mobile HIV-Testing Clinic
Date: Aug-09-2012A research article by Katharina Kranzer from the London School of Hygiene & Tropical Medicine and colleagues describe the feasibility and costs of an active tuberculosis case finding project in Cape Town, South Africa. The study describes the integration of tuberculosis testing into a mobile HIV testing service for HIV-negative individuals with symptoms suggestive of tuberculosis and all HIV-positive individuals...
Treatment Target For Diabetes, Wolfram Syndrome
Date: Aug-09-2012Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children with many symptoms, including juvenile-onset diabetes. Now a molecule has been identified that's key to the cell stress-modulated inflammation that causes insulin cells to die, report scientists at Washington University School of Medicine in St. Louis, the University of Massachusetts Medical School in Worcester and elsewhere...
New Model Synapse Could Shed Light On Disorders Such As Epilepsy And Anxiety
Date: Aug-09-2012A new way to study the role of a critical neurotransmitter in disorders such as epilepsy, anxiety, insomnia, depression, schizophrenia, and alcohol addiction has been developed by a group of scientists led by Gong Chen, an associate professor of biology at Penn State University. The new method involves molecularly engineering a model synapse -- a structure through which a nerve cell send signals to another cell. This model synapse can precisely control a variety of receptors for the neurotransmitter called GABA, which is important in brain chemistry...
Conflict-Of-Interest Declarations And Off-Label Drug Use
Date: Aug-09-2012Conflict-of-interest statements made by physicians and scientists in their medical journal articles after they had been allegedly paid by pharmaceutical manufacturers as part of off-label marketing programs are often inadequate, highlighting the deficiencies in relying on author candidness and the weaknesses in some journal practices in ensuring proper disclosure, according to a study by international researchers published in this week's PLOS Medicine...
Discovery Of New Atmospheric Compound Tied To Climate Change, Human Health
Date: Aug-09-2012An international research team led by the University of Colorado Boulder and the University of Helsinki has discovered a surprising new chemical compound in Earth's atmosphere that reacts with sulfur dioxide to form sulfuric acid, which is known to have significant impacts on climate and health...
Rheumatoid Arthritis Drugs: Study Compares Overall Mortality In TNF Inhibitors: Humira, Enbrel, And Remicade
Date: Aug-09-2012New research confirms no significant difference in the rates of death among patients with rheumatoid arthritis (RA) who were exposed to one of several TNF inhibitors used to treat RA, adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade). This population-based study of RA patients in Sweden - the first to compare mortality rates among patients treated with individual TNF inhibitors - is now available in Arthritis & Rheumatism, a journal published by Wiley on behalf of the American College of Rheumatology (ACR)...
Risk Disclosure Before Treatment Important To Patients
Date: Aug-09-2012Published in PLoS Medicine, the study showed that some doctors, particularly surgeons, are not explaining the risk of specific outcomes that matter most to patients. Overlooked risks that led to a legal claim or complaint included chronic pain, sexual dysfunction, visual or hearing loss, and the need for re-operation. Lead author Dr Marie Bismark from the University of Melbourne School of Population Health said the study revealed that doctors may routinely underestimate the importance patients place on understanding certain risks in advance of treatment...
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