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Trials Of New Targeted Cancer Drugs Reveal Lower Risk Of Serious Side-Effects
Date: Aug-09-2012Patients in early clinical trials of new-style targeted cancer therapies appear to have a much lower risk of the most serious side-effects than with traditional chemotherapy, according to a new analysis. Researchers at The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust analysed data from 36 Phase I trials run by the organisations' joint Drug Development Unit...
Analytic, But Not Creative, Problem-Solving Aided By Greater Working Memory Capacity
Date: Aug-09-2012Anyone who has tried to remember a ten-digit phone number or a nine-item grocery list knows that we can only hold so much information in mind at a given time. Our working memory capacity is decidedly finite - it reflects our ability to focus and control attention and strongly influences our ability to solve problems...
Pluristem Receives Approval To Commence A Phase I/II Study For Muscle Regeneration In Germany
Date: Aug-09-2012Pluristem Therapeutics, Inc. (NASDAQCM:PSTI; TASE: PLTR), a leading developer of placenta-based cell therapies, has announced it has received approval from the Paul-Ehrlich-Institute (PEI), the medical regulatory body in Germany, to commence a Phase I/II randomized, double blind, placebo controlled study to assess the safety and efficacy of its PLX cells, through intramuscular injections, for the regeneration of injured gluteal musculature following total hip replacement...
No Clinical Benefit Found For Corticosteroid Treatment Of Acute Sinusitis
Date: Aug-09-2012Corticosteroids, frequently prescribed to alleviate acute sinusitis, show no clinical benefit in treating the condition, according to a randomized controlled trial published in CMAJ (Canadian Medical Association Journal). The common cold is the main cause of acute sinusitis, which is characterized by inflammation of the nasal cavities, blocked nasal passages and sometimes headaches and facial pain. Allergies and bacteria can also cause the condition, which is uncomfortable and difficult to treat...
New Guide Provides Patients With Information About Reflux Disease And Its Connection To Barrett's Esophagus And Esophageal Cancer
Date: Aug-09-2012Every day, an estimated 25 million American adults suffer from heartburn. Some experts believe that 40 percent of adults experience heartburn every month. Despite these staggering statistics, few people understand the real risk that Heartburn can cause Cancer. The Esophageal Cancer Action Network (ECAN) has produced a free guide that provides patients with information about Reflux Disease and its connection to Barrett's Esophagus and Esophageal Cancer...
Dyslexia Caused By Signal Processing In The Brain
Date: Aug-09-2012To participate successfully in life, it is important to be able to read and write. Nevertheless, many children and adults have difficulties in acquiring these skills and the reason is not always obvious. They suffer from dyslexia which can have a variety of symptoms. Thanks to research carried out by Begona DÃaz and her colleagues at the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, a major step forward has been made in understanding the cause of dyslexia...
Team's Study Could Pave Way To Rejection-Free Adult Stem Cells
Date: Aug-09-2012Suppose patient-specific, blood-producing stem cells could be generated in the laboratory, eliminating the need for harvesting bone marrow - or finding a matching donor - for patients needing a bone marrow transplant? A German research team has generated blood-forming stem cells from pluripotent stem cells in the lab without using animal serum, a technique that could pave the way for production of rejection-free adult stem cells. Researchers Bernhard Schiedlmeier and Hannes Klump led the study, which appears in the current issue of STEM CELLS Translational Medicine...
New Gene Linked To PTSD Identified
Date: Aug-09-2012Investigators at Boston University School of Medicine (BUSM) and Veterans Affairs (VA) Boston Healthcare System have identified a new gene linked to post-traumatic stress disorder (PTSD). The findings, published online in Molecular Psychiatry, indicate that a gene known to play a role in protecting brain cells from the damaging effects of stress may also be involved in the development of PTSD...
Applying Animal Foraging Theory To Human Searches For Tumors
Date: Aug-09-2012If past experience makes you think there's going to be one more cashew at the bottom of the bowl, you're likely to search through those mixed nuts a little longer. But what keeps the attention of a radiologist who sees just 70 suspicious lesions in 1,000 mammograms or a baggage screener who hasn't found a handgun in more than a year? The answer, according to biological theory and a laboratory study conducted by Duke University psychologists, may be to make those professional searchers believe there are more targets to be found...
In Animal Models, TRPM7 Protein Found To Be Key To Breast Cancer Metastasis
Date: Aug-09-2012The protein transient receptor potential melastatin-like 7 (TRPM7) is a critical determinant of breast cancer cell metastasis, according to study results published in /iCancer Research, a journal of the American Association for Cancer Research. "The most important discovery that we report in this paper is that TRPM7 is required for metastasis, at least in a xenograft model of breast cancer metastasis," said Frank van Leeuwen, Ph.D., assistant professor at the Radbound University Medical Center in Nijmegen, the Netherlands...
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