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Common Signalling Pathway Discovered For Intellectual Disability In Fragile X And Down Syndromes

Date: Aug-07-2012
Intellectual disability due to Fragile X and Down syndromes involves similar molecular pathways report researchers in The EMBO Journal. The two disorders share disturbances in the molecular events that regulate the way nerve cells develop dendritic spines, the small extensions found on the surface of nerve cells that are crucial for communication in the brain...

Transplantation Barrier From Unexpected Variation In Immune Genes

Date: Aug-07-2012
Human HLA genes - the genes that allow our immune system to tell the difference between our own cells and foreign invaders - are evolving much more rapidly than previously thought, according to an article online in Trends in Genetics. The resulting degree of variation improves our ability to fight off disease, but could also present challenges to current worldwide efforts aimed at identifying potential donors for patients undergoing stem cell transplantation...

Concerns Over Widespread Gaps In Health Literacy And How To Bridge Them

Date: Aug-07-2012
Is it possible for a health care system to redesign its services to better educate patients to deal with their immediate health issues and also become more savvy consumers of medicine in the long run? The answer is yes, according to a study led by scientists at the University of California, San Francisco (UCSF) and San Francisco General Hospital and Trauma Center (SFGH) that was recently reported by the Institute of Medicine (IOM)...

A Novel Double-Stranded DNA Structure Identified

Date: Aug-07-2012
Double-stranded DNA has often been described as a right-handed helical structure, known as B-DNA. To perform its multiple functions, double-stranded DNA has multiple structures depending on conditions. For example, the melted DNA bubble forms during transcription elongation and the left-handed helical Z-DNA forms hypothetically during transcriptional regulations. Scientists have been proposing a novel form of double-stranded DNA structure since 1996. Referred to as 'S-DNA', it is produced from stretching the B-form DNA beyond a certain 'transition force' of around 65 pN to approximately 1...

3D Movie At 'Ultra-Resolution' Shows How Cell's Machinery Bends Membrane Inwards

Date: Aug-07-2012
Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have combined the power of two kinds of microscope to produce a 3-dimensional movie of how cells 'swallow' nutrients and other molecules by engulfing them. The study, published in Cell, is the first to follow changes in the shape of the cell's membrane and track proteins thought to influence those changes. It also provides ample data to investigate this essential process further. This 'swallowing', called endocytosis, is involved in a variety of crucial tasks...

Protection Against UVA Rays Provided By Strawberry Extract

Date: Aug-07-2012
An experiment has shown that strawberry extract added to skin cell cultures acts as a protector against ultraviolet radiation as well as increasing its viability and reducing damage to DNA. Developed by a team of Italian and Spanish researchers, the study opens the door to the creation of photoprotective cream made from strawberries...

A Link Between Stem Cell Regulation And Cancer

Date: Aug-07-2012
Researchers at Mount Sinai School of Medicine, the University of Manchester, and the MD Anderson Cancer Center have found a new role for an oncogenic signaling pathway in embryonic stem cell (ESC) self-renewal and in reprogramming adult cells into an ESC-state, which will aid in the development of future cancer therapies. The findings promote the understanding of the self-renewal mechanism in embryonic stem cells and provide insight into the role of Aurka, an oncoprotein that is amplified in several human cancers. The research is published in the journal Cell Stem Cell...

Health Hazards Of Chemical Compounds In The Work Area: MAK Value Lowered For Chlorinated Biphenyls

Date: Aug-07-2012
Chlorinated biphenyls (PCBs) are a group of substances for which the 2012 List of MAK and BAT Values submitted by the Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) specifies new, and in this case, significantly lower values than previously recommended...

What Is Neuroscience?

Date: Aug-07-2012
Neuroscience, also known as Neural Science, is the study of how the nervous system develops, its structure, and what it does. Neuroscientists focus on the brain and its impact on behavior and cognitive functions. Not only is neuroscience concerned with the normal functioning of the nervous system, but also what happens to the nervous system when people have neurological, psychiatric and neurodevelopmental disorders. Neuroscience is often referred to in the plural, as neurosciences. Neuroscience has traditionally been classed as a subdivision of biology...

Inflammatory Pathways Key To Understanding Link Between Depressive Symptoms And Cancer Survival

Date: Aug-07-2012
Research from The University of Texas MD Anderson Cancer Center has found that symptoms of depression in patients with newly diagnosed metastatic kidney cancer are associated with survival and inflammatory gene regulation may explain this link. The study, published in the journal PLoS ONE, further explores the interplay between patient psychological condition, stress hormone regulation and the role of inflammatory gene expression. Although previous research indicates depression is connected with worse outcomes, questions remain about the specific factors involved...