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ADAM28-Mediated Cancer Metastasis
Date: Jun-12-2012ADAM28, a metalloproteinase belonging to the ADAM gene family, cleaves the von Willebrand factor (VWF) and inhibits VWF-mediated cancer cell apoptosis, thereby enhancing lung metastases, so inhibiting its expression gives a substantial reduction in lung metastases, according to a study published June 8 in the Journal of The National Cancer Institute. Several ADAMs are known to be found in tumors and are linked with both tumor growth and cancer progression in humans...
Research Offers New Perspectives In The Treatment Of Heart Disease
Date: Jun-12-2012In Switzerland, more than 20,000 people (37% of all deaths) die of cardiovascular disease caused by atherosclerosis each year. Treatment options are currently available to people who suffer from the disease but no drug can target solely the diseased areas, often leading to generalized side effects. Intravenous injection of a vasodilator (a substance that dilates blood vessels), such as nitroglycerin, dilates both the diseased vessels and the rest of our arteries...
Improved Understanding Of Placental Growth And Healthy Pregnancy
Date: Jun-12-2012Scientists at the Babraham Institute have gained a new understanding of how the growth of the placenta is regulated before birth, which has important implications for a healthy pregnancy. The research, published in the journal Nature Cell Biology shows that the controlled release of a specific molecule, called miR-675, slows down growth of the placenta before birth. RNA molecules are best known as the intermediary between the cell's DNA and the making of proteins necessary for cell function. However, there are also many RNA molecules with functions other than encoding proteins...
4 Gene Loci Discovered That Predispose People To The Most Common Subtype Of Migraine
Date: Jun-12-2012Researchers studied genetic data of more than 11 000 people and found altogether six genes that predispose to migraine without aura. Four of these genes are new and two of them confirm previous findings. The new genes identified in this study provide further evidence for the hypothesis that dysregulation of molecules important in transmitting signals between brain neurons contribute to migraine. Two of the genes support the hypothesis of a possible role of blood vessels and thus disturbances in blood flow...
How Cells' Common Sugar Molecules Influence Inflammation, Cancer Metastasis, And Related Conditions
Date: Jun-12-2012Scientists at The Scripps Research Institute have developed chemical compounds that can make key modifications to common sugar molecules ("glycans"), which are found on the surface of all cells in our body. The new study presents powerful new tools for studying these molecules' function, for example in cell signaling and immunity, and for investigating new treatments for chronic inflammation, autoimmune diseases, cancer metastasis, and related conditions...
Understanding Self-Assembly Of Tiny Living Machines May Lead To Development Of Methods To Treat Diseases At The Nanoscale
Date: Jun-12-2012Enabling bioengineers to design new molecular machines for nanotechnology applications is one of the possible outcomes of a study by University of Montreal researchers that was published in Nature Structural and Molecular Biology. The scientists have developed a new approach to visualize how proteins assemble, which may also significantly aid our understanding of diseases such as Alzheimer's and Parkinson's, which are caused by errors in assembly...
Breast Tumor Signatures Found That Predict Treatment Response
Date: Jun-12-2012Decoding the DNA of patients with advanced breast cancer has allowed scientists to identify distinct cancer "signatures" that could help predict which women are most likely to benefit from estrogen-lowering therapy, while sparing others from unnecessary treatment. Researchers at Washington University School of Medicine in St. Louis uncovered mutations linked to whether or not women respond to aromatase inhibitors, drugs often prescribed to shrink large tumors before surgery...
New Test Identifies Patients Who Will Not Respond To The Painkiller Tramadol
Date: Jun-12-2012French researchers have found a way to identify quickly the 5-10% of patients in whom the commonly used painkiller, tramadol, does not work effectively. A simple blood test can produce a result within a few hours, enabling doctors to switch a non-responding patient on to another painkiller, such as morphine, which will be able to work in these patients. Dr Laurent Varin, an anaesthesiologist at the Caen Teaching Hospital (Caen, France), presented the findings to the European Anaesthesiology Congress in Paris...
Clinical Trials Of A First-Generation Artificial Pancreas System
Date: Jun-12-2012Results from the first feasibility study of an advanced first-generation artificial pancreas system were presented at the 72nd Annual American Diabetes Association Meeting in Philadelphia. Findings from the study indicated that the Hypoglycemia-Hyperglycemia Minimizer (HHM) System was able to automatically predict a rise and fall in blood glucose and correspondingly increase and/or decrease insulin delivery safely. The HHM System included a continuous, subcutaneous insulin pump, a continuous glucose monitor (CGM) and special software used to predict changes in blood glucose...
Happiness Is Significantly Affected By Neuroticism
Date: Jun-12-2012Having more money does not necessarily lead to happiness, especially if the person is neurotic, researchers from the University of Warwick, England, and the University of Minnesota, USA, reported in a CAGE (Centre for Competitive Advantage in the Global Economy) document. Dr. Eugenia Proto, from the Centre for Competitive Advantage in the Global Economy, University of Warwick, examined how personality features may impact on how people feel about their income, with regard to different levels of life satisfaction. Dr...
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