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Risk Of Death For Heart Failure Patients May Be Predicted By Emergency Department Algorithm
Date: Jun-06-2012Physicians can reduce the number of heart failure deaths and unnecessary hospital admissions by using a new computer-based algorithm developed at the Institute for Clinical Evaluative Sciences (ICES) that calculates each patient's individual risk of death. Published in the Annals of Internal Medicine, the algorithm improves upon clinical decision-making and determines whether or not a patient with heart failure should be admitted to hospital...
In Rat Model, Mature Liver Cells Better Than Stem Cells For Liver Cell Transplantation Therapy
Date: Jun-06-2012After carrying out a study comparing the repopulation efficiency of immature hepatic stem/progenitor cells and mature hepatocytes transplanted into liver-injured rats, a research team from Sapporo, Japan concluded that mature hepatocytes offered better repopulation efficiency than stem/progenitor cells. Until day 14 post-transplantation, the growth of the stem/progenitor cells was faster than the mature hepatocytes, but after two weeks most of the stem/progenitor cells had died. However, the mature hepatocytes continued to survive and proliferate one year after their implantation...
Immune Therapy For Cancer Ready For Wider Testing
Date: Jun-06-2012Two clinical trials led by Johns Hopkins Kimmel Cancer Center researchers in collaboration with other medical centers, testing experimental drugs aimed at restoring the immune system's ability to spot and attack cancer, have shown promising early results in patients with advanced non-small cell lung cancer, melanoma, and kidney cancer. More than 500 patients were treated in the studies of two drugs that target the same immune-suppressive pathway, and the investigators say there is enough evidence to support wider testing in larger groups of patients...
Medicare Auction Will Likely Face Severe Difficulties
Date: Jun-06-2012Medicare's new method for buying medical supplies and equipment - everything from wheelchairs and hospital beds to insulin shots and oxygen tanks - is doomed to face severe difficulties, according to a new study by Caltech researchers. The Center for Medicare and Medicaid Services (CMS) implemented the purchasing process - a novel type of auction - in nine metropolitan areas across the country last year and plans to expand it to 91 in 2013...
New Statistical Model Developed To Predict Future Medical Conditions
Date: Jun-06-2012Analyzing medical records from thousands of patients, statisticians have devised a statistical model for predicting what other medical problems a patient might encounter. Like how Netflix recommends movies and TV shows or how Amazon.com suggests products to buy, the algorithm makes predictions based on what a patient has already experienced as well as the experiences of other patients showing a similar medical history. "This provides physicians with insights on what might be coming next for a patient, based on experiences of other patients...
Surgical Site Infections And Rehospitalizations
Date: Jun-06-2012Preventing further complications in patients who develop infections after surgery to replace a knee or hip could save the U.S. healthcare system as much as $65 million annually, according to an analysis presented at the 39th Annual Educational Conference and International Meeting of the Association for Professionals in Infection Control and Epidemiology (APIC)...
Antibiotic Ointments Overused And Misused By N.Y. Prison Inmates
Date: Jun-06-2012Prisoners need education on the appropriate use of topical antibiotic products, according to a study released at the 39th Annual Educational Conference and International Meeting of the Association for Professionals in Infection Control and Epidemiology (APIC)...
Regular, Moderate Exercise Most Beneficial, While Excessive Endurance Training Can Be Too Much Of A Good Thing
Date: Jun-06-2012Micah True, legendary ultra-marathoner, died suddenly while on a routine 12-mile training run March 27, 2012. The mythic Caballo Blanco in the best-selling book, Born to Run, True would run as far as 100 miles in a day. On autopsy his heart was enlarged and scarred; he died of a lethal arrhythmia (irregularity of the heart rhythm). Although speculative, the pathologic changes in the heart of this 58 year-old veteran extreme endurance athlete may have been manifestations of "Phidippides cardiomyopathy," a condition caused by chronic excessive endurance exercise...
Immune System Glitch Identified Which Is Linked To A Fourfold Higher Likelihood Of Death
Date: Jun-06-2012Mayo Clinic researchers have identified an immune system deficiency whose presence shows someone is up to four times likelier to die than a person without it. The glitch involves an antibody molecule called a free light chain; people whose immune systems produce too much of the molecule are far more likely to die of a life-threatening illness such as cancer, diabetes and cardiac and respiratory disease than those whose bodies make normal levels. The study is published in the June issue of Mayo Clinic Proceedings...
Expanding The Genetic Alphabet May Be Easier Than Previously Thought
Date: Jun-06-2012A new study led by scientists at The Scripps Research Institute suggests that the replication process for DNA - the genetic instructions for living organisms that is composed of four bases (C, G, A and T) - is more open to unnatural letters than had previously been thought. An expanded "DNA alphabet" could carry more information than natural DNA, potentially coding for a much wider range of molecules and enabling a variety of powerful applications, from precise molecular probes and nanomachines to useful new life forms...
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