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Detailing Protein Pathways May Provide Clues In Leukemia Research
Date: Jun-05-2012Scientists at Rice University and the University of Texas MD Anderson Cancer Center have successfully profiled protein pathways found to be distinctive to leukemia patients with particular variants of the disease. Their research involved the creation of a new computational approach to identifying complex networks in protein signaling. They reported their work this month in the journal Proteomics. With their new method, Rice bioengineer Amina Qutub, MD Anderson clinician and scientist Steven Kornblau and Rice graduate student Heather York analyzed more than a decade's worth of data...
The Majority Of Emergency Department Patients Who Receive CT Of The Abdomen And Pelvis Are Clinically Complex
Date: Jun-05-2012The overwhelming majority (93.8 percent) of patients undergoing computed tomography (CT) of the abdomen and pelvis (CTAP) in the emergency department (ED) setting are classified as clinically complex, according to a study in the June issue of the Journal of the American College of Radiology. Clinically complex is used to describe patients who are, based on documentation of their ED physician, much sicker than others. Increasing clinical evidence has validated the utility of CTAP in a variety of clinical settings...
The Structure Of 'Batteries' Of The Biological Clock
Date: Jun-05-2012Howard Hughes Medical Institute scientists have determined the three-dimensional structure of two proteins that help keep the body's clocks in sync. The proteins, CLOCK and BMAL1, bind to each other to regulate the activity of thousands of genes whose expression fluctuates throughout the course of a day. Knowing the structure of the CLOCK:BMAL1 complex will help researchers understand the intricacies of how this regulation is carried out and how mutations in each protein lead the biological clock to go awry...
Increasing Fiber In Adolescents' Diets Has Many Health Benefits
Date: Jun-05-2012Adolescents who don't eat enough fiber tend to have bigger bellies and higher levels of inflammatory factors in their blood, both major risk factors for cardiovascular disease and diabetes, researchers report. The study of 559 adolescents age 14-18 from Augusta, Ga., showed they consumed on average about one-third of the daily recommended amount of fiber, said Dr. Norman Pollock, bone biologist at the Medical College of Georgia and the Institute of Public and Preventive Health at Georgia Health Sciences University...
Link Between Maternal Smoking And Severe Asthma In Teen Years
Date: Jun-05-2012African-American and Latino children whose mothers smoked during pregnancy are more likely to suffer from acute asthma symptoms in their teens than asthma sufferers whose mothers did not smoke, according to a new study led by a research team at UCSF...
Study Of 2 Million Patients Looks At Vena Cava Filters, Outlines Embolism Treatments
Date: Jun-05-2012A filter used to block clots from passing from the veins in the legs to the arteries of the lung does not improve mortality rates for most patients suffering a pulmonary embolism. However, if a patient is unstable - in shock or requires a ventilator - filters can save lives. Furthermore, for unstable patients with a pulmonary embolism, it is crucial they receive clot-dissolving medications known as thrombolytic therapy...
Notch Network Findings Further The Development Of Cancer, Heart Disease Therapeutics
Date: Jun-05-2012By using laser microbeam technology called optical tweezers, UC Irvine and UCLA researchers have uncovered fundamental properties of a key molecular signaling system involved with development, cancer and cardiovascular disease. In collaboration, UCI's Elliot Botvinick and UCLA's Gerry Weinmaster published online in the journal Developmental Cell complementary studies in which they each used optical tweezers to detect and measure the mechanical force produced by cells when bound to Notch, a cellular pathway that ensures the correct cell types form at a precise time and location in the body...
Researchers Investigate 'Healthy' Obesity Gene
Date: Jun-05-2012Why is it that some obese people are healthier than others? This was one of the main questions Dr. Chaodong Wu of the College of Agriculture and Life Sciences - Texas A&M University System - and a group of researchers tried to answer in a recent study. The study, which will appear in a July issue of the Journal of Biological Chemistry, used genetically modified mice to investigate the genetic aspects of why some obese people do not develop certain medical problems typically associated with obesity, especially Type 2 diabetes. Wu noted that Xin Guo, a Ph.D...
Causal Link Investigated Between Alcohol Consumption And Atrial Fibrillation
Date: Jun-05-2012The term "holiday heart syndrome" was coined in a 1978 study to describe patients with atrial fibrillation who experienced a common and potentially dangerous form of heart palpitation after excessive drinking, which can be common during the winter holiday season. The symptoms usually went away when the revelers stopped drinking. Now, research from UCSF builds on that finding, establishing a stronger causal link between alcohol consumption and serious palpitations in patients with atrial fibrillation, the most common form of arrhythmia...
During Radiation Treatment For Prostate Cancer The Antioxidant Beta-Carotene Found To Be Safe
Date: Jun-05-2012Despite past safety concerns, the antioxidant supplement beta-carotene, is safe to use during radiation therapy treatments for prostate cancer and does not increase the risk of prostate cancer death or metastases, according to a study in the International Journal of Radiation Oncology�Biology�Physics, the official scientific journal of the American Society for Radiation Oncology (ASTRO). The use of vitamin supplements and antioxidants is common, but the safety of using antioxidant supplements during radiation treatments for prostate cancer is controversial...
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