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Mechanism discovered that helps HIV evade antibodies, stabilize key proteins
Date: Feb-06-2014NIH scientists have discovered a mechanism involved in stabilizing key HIV proteins and thereby concealing sites where some of the most powerful HIV neutralizing antibodies bind, findings with potential implications for HIV vaccine research. Numerous spikes jut out of the surface of HIV, each containing a set of three identical, bulb-shaped proteins called gp120 that can be closed together or spread apart like the petals of a flower.
Mechanism discovered that helps HIV evade antibodies, stabilize key proteins
Date: Feb-06-2014NIH scientists have discovered a mechanism involved in stabilizing key HIV proteins and thereby concealing sites where some of the most powerful HIV neutralizing antibodies bind, findings with potential implications for HIV vaccine research. Numerous spikes jut out of the surface of HIV, each containing a set of three identical, bulb-shaped proteins called gp120 that can be closed together or spread apart like the petals of a flower.
How a shape-shifting DNA-repair machine fights cancer
Date: Feb-06-2014Maybe you've seen the movies or played with toy Transformers, those shape-shifting machines that morph in response to whatever challenge they face. It turns out that DNA-repair machines in your cells use a similar approach to fight cancer and other diseases, according to research led by scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab).As reported in a pair of new studies, the scientists gained new insights into how a protein complex called Mre11-Rad50 reshapes itself to take on different DNA-repair tasks.
How a shape-shifting DNA-repair machine fights cancer
Date: Feb-06-2014Maybe you've seen the movies or played with toy Transformers, those shape-shifting machines that morph in response to whatever challenge they face. It turns out that DNA-repair machines in your cells use a similar approach to fight cancer and other diseases, according to research led by scientists from the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab).As reported in a pair of new studies, the scientists gained new insights into how a protein complex called Mre11-Rad50 reshapes itself to take on different DNA-repair tasks.
Insight into why cancer incidence increases with age
Date: Feb-06-2014The accumulation of age-associated changes in a biochemical process that helps control genes may be responsible for some of the increased risk of cancer seen in older people, according to a National Institutes of Health study.Scientists have known for years that age is a leading risk factor for the development of many types of cancer, but why aging increases cancer risk remains unclear. Researchers suspect that DNA methylation, or the binding of chemical tags, called methyl groups, onto DNA, may be involved.
Insight into why cancer incidence increases with age
Date: Feb-06-2014The accumulation of age-associated changes in a biochemical process that helps control genes may be responsible for some of the increased risk of cancer seen in older people, according to a National Institutes of Health study.Scientists have known for years that age is a leading risk factor for the development of many types of cancer, but why aging increases cancer risk remains unclear. Researchers suspect that DNA methylation, or the binding of chemical tags, called methyl groups, onto DNA, may be involved.
In screening mammography, novel technique increases detection rate
Date: Feb-06-2014Digital mammography screening with new photon-counting technique offers high diagnostic performance, according to a study published online in the journal Radiology.As mammography screening has shifted to digital technology, a range of computed radiography (CR) and direct radiography (DR) systems have emerged. The photon-counting technique is a promising DR approach that uses a unique detector to decrease scattered radiation and noise, enabling dose reduction and making it a promising tool for screening.
In screening mammography, novel technique increases detection rate
Date: Feb-06-2014Digital mammography screening with new photon-counting technique offers high diagnostic performance, according to a study published online in the journal Radiology.As mammography screening has shifted to digital technology, a range of computed radiography (CR) and direct radiography (DR) systems have emerged. The photon-counting technique is a promising DR approach that uses a unique detector to decrease scattered radiation and noise, enabling dose reduction and making it a promising tool for screening.
Novel simplified IVF procedure leads to first live births
Date: Feb-06-2014A recent prospective study published in Reproductive BioMedicine Online comparing conventional IVF with a novel simplified laboratory method of culturing embryos suggested that fertilization and implantation rates were similar for the simplified system when compared with those reported by conventional IVF programs. Sixteen healthy babies have already been born with this new method. According to the results of this study, IVF may be offered at a more reasonable price and made available to a larger part of the world population.
Vaccine barriers: 30,000 adults die of preventable diseases each year
Date: Feb-06-2014Researchers from the University of Colorado in Denver have conducted a study examining adult vaccination, revealing a public health concern over the "stubbornly low" vaccination rates in adults. They note that 30,000 people in the US die of vaccine-preventable diseases each year, the majority of whom are adults.Published in the journal Annals of Internal Medicine, the study was led by Dr. Laura Hurley, assistant professor of medicine at the University of Colorado (CU) School of Medicine.
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