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Multiple medication use 'not always hazardous,' say researchers
Date: Jan-16-2014New research finds that patients with a single illness who take multiple drugs - referred to as "polypharmacy" - have a higher risk of hospital admission, compared with polypharmacy patients with multiple health conditions, who have a "near-normal" admission risk. This is according to a study published in the British Journal of Clinical Pharmacology.The study researchers, led by Dr.
An incurable form of blindness may be improved by gene therapy
Date: Jan-16-2014Scientists at the University of Oxford in the UK have restored some sight in people who have a degenerative eye disease by replacing a defective gene in their retinas with a working version of the same gene.The people who received the procedure - which is delivered using a single injection - have an inherited type of genetic blindness called choroideremia, which is caused by a mutation in the CHM gene. Choroideremia affects about 1 in 50,000, and people who have this condition get progressively worse vision, eventually becoming completely blind around middle age.
An incurable form of blindness may be improved by gene therapy
Date: Jan-16-2014Scientists at the University of Oxford in the UK have restored some sight in people who have a degenerative eye disease by replacing a defective gene in their retinas with a working version of the same gene.The people who received the procedure - which is delivered using a single injection - have an inherited type of genetic blindness called choroideremia, which is caused by a mutation in the CHM gene. Choroideremia affects about 1 in 50,000, and people who have this condition get progressively worse vision, eventually becoming completely blind around middle age.
Just a brief visit to a neighborhood induces the social attitudes of that neighborhood
Date: Jan-16-2014Spending as little as 45 minutes in a high-crime, deprived neighbourhood can have measurable effects on people's trust in others and their feelings of paranoia. In a new study, students who visited high crime neighbourhoods quickly developed a level of trust and paranoia comparable to the residents of that neighbourhood, and significantly different from that in more low-crime neighbourhoods. As a result, urban planners should carefully consider the psychological effects of the environment.
Just a brief visit to a neighborhood induces the social attitudes of that neighborhood
Date: Jan-16-2014Spending as little as 45 minutes in a high-crime, deprived neighbourhood can have measurable effects on people's trust in others and their feelings of paranoia. In a new study, students who visited high crime neighbourhoods quickly developed a level of trust and paranoia comparable to the residents of that neighbourhood, and significantly different from that in more low-crime neighbourhoods. As a result, urban planners should carefully consider the psychological effects of the environment.
Small molecule BMH-21 shows promise as anti-cancer therapy
Date: Jan-16-2014Johns Hopkins scientists say a previously known but little studied chemical compound targets and shuts down a common cancer process. In studies of laboratory-grown human tumor cell lines, the drug disrupted tumor cell division and prevented growth of advanced cancer cells.In a study described in the journal Cancer-Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH-21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicate.
How long does postpartum depression really last?
Date: Jan-16-2014A new, comprehensive review of clinical studies examining postpartum depression has shown that although symptoms of postpartum depression in most women recede over time, for a large number of women, depression remains a long-term problem.Although it is common to experience mood swings or become tearful in the weeks following childbirth, in some women these symptoms may become more persistent and severe, and could be an indication of postpartum depression.
Key proteins identified that are responsible for electrical communication in the heart
Date: Jan-16-2014Findings shed light on the root of healthy heart function and reveal a class of drugs that can prevent erratic heartbeats tied to heart attacks, strokes and other health conditionsCedars-Sinai Heart Institute researchers have found that six proteins - five more than previously thought - are responsible for cell-to-cell communication that regulates the heart and plays a role in limiting the size of heart attacks and strokes.The smallest of these proteins directs the largest in performing its role of coordinating billions of heart cells during each heartbeat.
Small RNAs coordinate bacterial attack on epithelial cells
Date: Jan-16-2014Two small RNAs (sRNAs) working in concert enable the deadly enterohemorrhagic Escherichia coli (EHEC) 0157:H7 to attach to and initiate infection in epithelial cells that line the digestive tract, according to a study published in mBio®, the online open-access journal of the American Society for Microbiology.
Robot-assisted partial nephrectomy for kidney cancer preserves kidney function
Date: Jan-16-2014Patients with chronic kidney disease who received robot-assisted partial nephrectomy to treat kidney cancer have minimal loss of kidney function -- a smaller amount even than patients with normal kidney function, according to researchers at Henry Ford Hospital's Vattikuti Urology Institute.The study, which includes patient data from five U.S. medical centers, is the largest of its kind.The study is published online ahead of print in European Urology, the journal of the European Association of Urology.
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