Inducing neural differentiation via Noggin and bFGF

Date: Sep-18-2013The difference between Noggin and basic fibroblast growth factor for the neural precursor differentiation from human embryonic stem cells has not been studied.

Prof. Xuejin Chen and colleagues from Shanghai Jiao Tong University were the first to utilize 100 µg/L Noggin or 20 µg/L basic fibroblast growth factor in serum-free neural induction medium to differentiate human embryonic stem cells H14 into neural precursors using monolayer differentiation.

The researchers found that Noggin has a greater effect than basic fibroblast growth factor on the induction of human embryonic stem cell differentiation into neural precursors by monolayer differentiation, as Noggin accelerates and increases the differentiation of neural precursors.

These findings were published in Neural Regeneration Research (Vol. 8, No. 23, 2013).

Zhang Y, Zhou JM, Fang ZF, Jiang MX, Chen XJ. Noggin versus basic fibroblast growth factor on the differentiation of human embryonic stem cells. Neural Regen Res. 2013;8(23):2171-2177.

Courtesy: Medical News Today Note: Any medical information available in this news section is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional.